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pentobarbital decreases amounts of toremifene by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. CYP3A4 inducers maximize charge of toremifene metabolism, decreasing the regular-point out concentration in serum.pentobarbital will lower the extent or effect of theophylline by affecting hepatic/intestinal enzyme CYP3A4 metab